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GPX4 deficiency enhanced cellular LPO and specifically attenuated the STING DNA-sensing pathway, thereby inhibiting innate antiviral immune responses against HSV-1 and promoting HSV-1 replication in vivo (Jia et al., 2020) These suggested that GPX4 facilitated STING activation by maintaining redox homeostasis of lipids (Jia et al., 2020)

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